Neurobiology of Disease Excessive Extracellular Volume Reveals a Neurodegenerative Pattern in Schizophrenia Onset

Ofer Pasternak,1 Carl-Fredrik Westin,2 Sylvain Bouix,1 Larry J. Seidman,4,6 Jill M. Goldstein,1,3,4 Tsung-Ung W. Woo,5 Tracey L. Petryshen,6,7,8 Raquelle I. Mesholam-Gately,4 Robert W. McCarley,4,9 Ron Kikinis,2 Martha E. Shenton,1,9 and Marek Kubicki1 Departments of 1Psychiatry, 2Radiology, and 3Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, 4Massachusetts Mental Health Center, Public Psychiatry Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, 5Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, 6Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, 7Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Boston, Massachusetts 02142, 8Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02144, and 9Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Brockton, Massachusetts 02301